⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24029798 | 0.84 | — | — | |
| SCHEMBL5586344 | 0.74 | — | — | |
| SCHEMBL18358847 | 0.67 | — | — | |
| SCHEMBL18358940 | 0.67 | — | — | |
| SCHEMBL18358925 | 0.67 | — | — | |
| SCHEMBL13815121 | 0.65 | — | — | |
| SCHEMBL1584140 | 0.65 | — | — | |
| SCHEMBL7745208 | 0.65 | — | — | |
| SCHEMBL30973549 | 0.65 | — | — | |
| SCHEMBL18535098 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065022-A2 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-05-18 | — | — | WO | disclosed |