Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mirtazapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 8/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 6/20 | 0.97 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 2/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.97 |
| ▸ | HTR2B | P41595 | 6/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
| ▸ | HTR1A | P08908 | 5/20 | 0.97 |
| ▸ | HTR3A | P46098 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | DRD1 | P21728 | 2/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.97 |
| ▸ | HTR7 | P34969 | 2/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.97 |
| ▸ | HRH1 | P35367 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mirtazapine SCHEMBL29579914 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL29484433 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Esmirtazapine SCHEMBL49330 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL966891 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Esmirtazapine SCHEMBL29579803 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL8271559 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL35408 | 0.99 | HTR2A (1.00) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL5666018 | 0.97 | HTR2A (0.97) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL355514 | 0.97 | HTR2A (0.97) | HTR2AHTR2CHTR2BDRD3HTR1A | |
| Mirtazapine SCHEMBL2483266 | 0.97 | HTR2A (0.97) | HTR2AHTR2CHTR2BDRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499303-A4 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2007-07-25 | — | — | EP | disclosed |
| EP-1499303-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | Miller, Fred H. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003086267-A2 | MULTI-PHASE, MULTI-COMPARTMENT CAPSULAR SYSTEM | MILLER FRED H (US) | 2003-10-23 | — | — | WO | disclosed |