SCHEMBL5591095

SCHEMBL5591095

O=C(Nc1nc(-c2cccc(C(F)(F)F)c2F)cs1)c1cnc(N2CCC(C(=O)O)C2)c(Cl)c1.[NaH]

nearest known ligand 0.91

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MPL P40238 20/20 0.91

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5591106 0.95 MPL (1.00) MPL
SCHEMBL5591075 0.95 MPL (1.00) MPL
SCHEMBL5591028 0.95 MPL (1.00) MPL
SCHEMBL5591115 0.94 MPL (0.88) MPL
SCHEMBL5591094 0.92 MPL (0.82) MPL
SCHEMBL5591108 0.92 MPL (0.84) MPL
Phosphoric Acid SCHEMBL5591012 0.91 MPL (0.92) MPL
SCHEMBL5590973 0.91 MPL (0.82) MPL
SCHEMBL5591203 0.91 MPL (0.87) MPL
SCHEMBL5591329 0.91 MPL (0.82) MPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007004038-A1 AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR PFIZER PRODUCTS INC. (US) 2007-01-11 WO claimed
WO-2007004038-A1 AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR PFIZER PRODUCTS INC. (US) 2007-01-11 WO disclosed