Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 8/20 | 0.62 |
| ▸ | PAK4 | O96013 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606046 | 1.00 | PAK1 (0.62) | PAK1PAK4NTRK1IGF1RGSK3B | |
| SCHEMBL22054248 | 0.75 | PAK1 (0.56) | PAK1PAK4IGF1RGSK3BDYRK3 | |
| SCHEMBL30250190 | 0.74 | PAK1 (0.76) | PAK1PAK4NTRK1IGF1RJAK2 | |
| SCHEMBL30250341 | 0.73 | PAK1 (0.78) | PAK1PAK4NTRK1IGF1RRET | |
| SCHEMBL23889520 | 0.73 | PAK1 (0.63) | PAK1PAK4IGF1RGSK3BDYRK3 | |
| SCHEMBL30147226 | 0.73 | PAK1 (0.60) | PAK1PAK4NTRK1IGF1RGSK3B | |
| SCHEMBL14606095 | 0.73 | PAK1 (0.60) | PAK1PAK4NTRK1IGF1RGSK3B | |
| SCHEMBL23889650 | 0.72 | PAK1 (0.55) | PAK1PAK4IGF1RGSK3BDYRK3 | |
| SCHEMBL14605895 | 0.72 | PAK1 (0.65) | PAK1PAK4IGF1RGSK3BDYRK3 | |
| SCHEMBL24175120 | 0.72 | PAK1 (0.59) | PAK1PAK4NTRK1IGF1RGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |