SCHEMBL5592015

SCHEMBL5592015

O=C(O)N1CCC(COCCc2cc(Br)cc(C(F)(F)F)c2)(c2ccccc2)CC1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.60
SLC6A4 P31645 5/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3587282 0.90 TACR1 (0.73) TACR1SLC6A4
SCHEMBL5592022 0.90 TACR1 (0.73) TACR1SLC6A4
SCHEMBL5591958 0.87 TACR1 (0.46) TACR1SLC6A4
SCHEMBL3592468 0.83 TACR1 (0.62) TACR1SLC6A4
SCHEMBL5591983 0.82 TACR1 (0.67) TACR1
SCHEMBL3586501 0.81 TACR1 (0.68) TACR1SLC6A4
SCHEMBL3594793 0.80 TACR1 (0.88) TACR1SLC6A4
SCHEMBL5452238 0.78 TACR1 (0.73) TACR1SLC6A4
SCHEMBL3594030 0.78 TACR1 (0.73) TACR1SLC6A4
SCHEMBL3595143 0.78 TACR1 (0.60) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007121389-A2 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AS NK-I AND SEROTONIN TRANSPORTER INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-10-25 WO disclosed