Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214535 | 0.85 | HRH3 (0.57) | HRH3CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL7092337 | 0.78 | HRH3 (0.69) | HRH3CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL1777051 | 0.75 | KDM4E (0.53) | HRH3 | |
| SCHEMBL1375936 | 0.74 | HRH3 (1.00) | HRH3KCNH2HTR3ACHRM2SLC6A2 | |
| SCHEMBL1375928 | 0.74 | HRH3 (1.00) | HRH3KCNH2HTR3ACHRM2SLC6A2 | |
| SCHEMBL240234 | 0.74 | HRH3 (0.62) | HRH3KCNH2HTR3ACHRM2SLC6A2 | |
| SCHEMBL240235 | 0.74 | HRH3 (0.62) | HRH3KCNH2HTR3ACHRM2SLC6A2 | |
| SCHEMBL5214957 | 0.74 | HRH3 (0.53) | HRH3CYP1A2CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL240602 | 0.74 | HRH3 (0.70) | HRH3KCNH2HTR3ACHRM2SLC6A2 | |
| SCHEMBL240603 | 0.74 | HRH3 (0.70) | HRH3KCNH2HTR3ACHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007138431-A2 | AZABICYCLIC ETHER HISTAMINE-3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-12-06 | — | — | WO | claimed |
| WO-2007138431-A2 | AZABICYCLIC ETHER HISTAMINE-3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2007-12-06 | — | — | WO | disclosed |