Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.71 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.71 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709514 | 1.00 | CXCR2 (0.71) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL5595077 | 0.84 | CXCR2 (0.85) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL7489930 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL7514963 | 0.82 | CXCR2 (0.73) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL6824309 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1ALDH1A1GAAMEN1 | |
| SCHEMBL3705632 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1ALDH1A1GAAMEN1 | |
| SCHEMBL3710548 | 0.81 | CXCR2 (0.71) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL7493701 | 0.80 | STAT3 (0.51) | CXCR2CXCR1CA12CA1CA2 | |
| SCHEMBL27576146 | 0.80 | CXCR2 (0.69) | CXCR2CA12CA1CA2CA9 | |
| SCHEMBL7489080 | 0.79 | CXCR2 (0.67) | CXCR2CXCR1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |