Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
| ▸ | PDE1A | P54750 | 3/20 | 0.68 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.68 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.68 |
| ▸ | PDE2A | O00408 | 1/20 | 0.68 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.68 |
| ▸ | PDE6D | O43924 | 1/20 | 0.68 |
| ▸ | PDE8A | O60658 | 1/20 | 0.68 |
| ▸ | PDE9A | O76083 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | PDE6A | P16499 | 1/20 | 0.68 |
| ▸ | PDE6G | P18545 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334389 | 0.93 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6334615 | 0.93 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6333008 | 0.91 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6332513 | 0.91 | PDE5A (0.72) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6338193 | 0.90 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL14836455 | 0.88 | PDE5A (0.75) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL5595162 | 0.88 | PDE5A (0.78) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6338376 | 0.87 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL5595563 | 0.86 | PDE5A (0.67) | PDE5APDE1APDE1BPDE1CABCC4 | |
| SCHEMBL6332267 | 0.86 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1CABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197560-A1 | cGMP PDE 5 inhibitors for inhalation in the treatment of sexual dysfunction | NAEF RETO | 2007-08-23 | — | — | US | disclosed |
| US-6916927-B2 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PFIZER INC. | 2005-07-12 | — | — | US | disclosed |
| US-20040214831-A1 | cGMP PDE 5 inhibitors for inhalation in the treatment of sexual dysfunction | NAEF RETO | 2004-10-28 | — | — | US | disclosed |
| US-20040180944-A1 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
| US-6723719-B1 | DYSMENORRHOEA, BENIGN PROSTATIC HYPERPLASIA (BPH), BLADDER OUTLET OBSTRUCTION, INCONTINENCE, AGINA, CONGESTIVE HEART FAILURE, ATHEROSCLEROSIS; HYPOTENSIVE AND ANTIALLERGEN AGENTS | PFIZER INC | 2004-04-20 | — | — | US | disclosed |
| US-20010055570-A1 | Cyclic guanosine 3',5'-monophosphate phosphodiesterases (cGMP PDEs); using specified pyrazolopyrimidinone or aminoquinazoline derivatives | NAEF RETO (CH) | 2001-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180944-A1 | Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP-PDE5) for the treatment of sexual dysfunction | PDE5A, PDE3A, PDE3B | PDE5A 1/4885PDE1A 38/4885PDE1B 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.