Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219219 | 0.87 | KDM4E (0.61) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL2739043 | 0.80 | KDM4E (0.59) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL680239 | 0.79 | KCNH2 (0.56) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL220817 | 0.78 | KDM4E (0.65) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL2739042 | 0.77 | KDM4E (0.67) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL5594717 | 0.76 | KDM4E (0.66) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL219784 | 0.74 | KDM4E (0.66) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL680655 | 0.73 | KDM4E (0.70) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL30388535 | 0.73 | KDM4E (0.70) | KDM4EHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL14749181 | 0.73 | KDM4E (0.70) | KDM4EHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778252-A2 | NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS | Barbeau, Donald L. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020573-A2 | NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS | BARBEAU DONALD L (US) | 2006-02-23 | — | — | WO | disclosed |