Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.73 |
| ▸ | PDE6D | O43924 | 1/20 | 0.46 |
| ▸ | PDE6A | P16499 | 1/20 | 0.46 |
| ▸ | PDE6G | P18545 | 1/20 | 0.46 |
| ▸ | PDE6B | P35913 | 1/20 | 0.46 |
| ▸ | PDE6C | P51160 | 1/20 | 0.46 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165080 | 0.85 | PDE5A (0.71) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5595725 | 0.85 | PDE5A (1.00) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7165068 | 0.83 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL6429060 | 0.83 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5595481 | 0.83 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7167812 | 0.82 | PDE5A (0.69) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7168971 | 0.80 | PDE5A (0.68) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7164710 | 0.80 | PDE5A (0.66) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5595693 | 0.77 | PDE5A (0.78) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7172367 | 0.76 | PDE5A (0.67) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173042-B2 | Quinoline inhibitors of cGMP phosphodiesterase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-02-06 | — | — | US | claimed |