Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.53 |
| ▸ | PDE4A | P27815 | 15/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537326 | 1.00 | PDE4B (0.53) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL5595599 | 0.89 | PDE4A (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537067 | 0.89 | PDE4A (0.59) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537199 | 0.87 | PDE4B (0.72) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537327 | 0.83 | PDE4B (0.56) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL5595708 | 0.83 | PDE4B (0.56) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537194 | 0.83 | PDE4B (0.75) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537164 | 0.83 | PDE4B (0.75) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537252 | 0.78 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DHTR2B | |
| SCHEMBL537054 | 0.78 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228071-B1 | PHARMACEUTICALLY ACTIVE ISOINDOLINE DERIVATIVES | CELGENE CORP (US) | 2007-03-28 | — | — | EP | claimed |