Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 10/20 | 0.44 |
| ▸ | CCNH | P51946 | 10/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.44 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.44 |
| ▸ | CCNK | O75909 | 7/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10166353 | 1.00 | CDK7 (0.44) | CDK7CCNHMNAT1CDK2CCNA2 | |
| SCHEMBL559649 | 1.00 | CDK7 (0.44) | CDK7CCNHMNAT1CDK2CCNA2 | |
| SCHEMBL558705 | 0.87 | ROCK1 (0.49) | RIPK2ADORA2AADORA2BADORA1 | |
| SCHEMBL559592 | 0.87 | ROCK1 (0.49) | RIPK2ADORA2AADORA2BADORA1 | |
| SCHEMBL558706 | 0.87 | ROCK1 (0.49) | RIPK2ADORA2AADORA2BADORA1 | |
| SCHEMBL559591 | 0.87 | ROCK1 (0.49) | RIPK2ADORA2AADORA2BADORA1 | |
| SCHEMBL559278 | 0.87 | MAPK8 (0.46) | CDK7CCNHMNAT1CDK2CCNA2 | |
| SCHEMBL559277 | 0.87 | MAPK8 (0.46) | CDK7CCNHMNAT1CDK2CCNA2 | |
| SCHEMBL559275 | 0.80 | ROCK1 (0.46) | CDK7CCNHMNAT1CDK2CCNA2 | |
| SCHEMBL10166363 | 0.80 | ROCK1 (0.46) | CDK7CCNHMNAT1CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | CDK7 660/4885CCNH 2591/4885MNAT1 173/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | CDK7 660/4885CCNH 2591/4885MNAT1 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.