Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29983575 | 1.00 | PARP1 (0.46) | PARP1KDM4ETDP1NPC1ALDH1A1 | |
| SCHEMBL17793760 | 0.85 | KDM4E (0.65) | KDM4ETDP1NPC1ALDH1A1MAPT | |
| SCHEMBL4186883 | 0.80 | KDM4E (0.65) | PARP1KDM4ETDP1NPC1ALDH1A1 | |
| SCHEMBL30810276 | 0.80 | PARP1 (0.45) | PARP1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL30517722 | 0.79 | CSNK1A1 (0.50) | PARP1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL995828 | 0.79 | CSNK1A1 (0.50) | PARP1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL31619658 | 0.78 | PARP1 (0.44) | PARP1KDM4ETDP1NPC1ALDH1A1 | |
| SCHEMBL10406074 | 0.77 | PARP1 (0.46) | PARP1KDM4ETDP1NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30810223 | 0.77 | CSNK1A1 (0.49) | PARP1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL31238942 | 0.77 | PARP1 (0.46) | PARP1KDM4ETDP1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | claimed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | claimed |
| CN-107501258-A | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2017-12-22 | — | — | CN | claimed |
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | claimed |
| WO-2005044194-A2 | TREATMENT OR PREVENTION OF NEOPLASIA BY USE OF AN Hsp90 INHIBITOR | PHARMACIA CORPORATION (US) | 2005-05-19 | — | — | WO | claimed |
| CN-107501258-B8 | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 青岛大学附属医院 | 2018-10-16 | — | — | CN | disclosed |
| CN-107501258-B8 | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 青岛大学附属医院 | 2018-10-16 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | disclosed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | disclosed |
| CN-107501258-A | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2017-12-22 | — | — | CN | disclosed |
| CN-104254534-B | Modulators of HEC1 activity and methods thereof | 泰纬生命科技股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-104254534-A | Modulators of HEC1 activity and methods thereof | TAIVEX THERAPEUTICS CORP | 2014-12-31 | — | — | CN | disclosed |
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | disclosed |
| WO-2006129257-A2 | KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-12-07 | — | — | WO | disclosed |
| CN-1812964-A | Heterocyclic methyl sulfone derivative | DAIICHI SEIYAKU CO (JP) | 2006-08-02 | — | — | CN | disclosed |
| EP-1682143-A2 | COMBINATIONS COMPRISING AN HSP90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | Pharmacia Corporation (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005041879-A2 | COMBINATIONS COMPRISING AN Hsp90 INHIBITOR AND A PHOPHODIESTERASE INHIBITOR FOR TREATING OR PREVENTING NEOPLASIA | PHARMACIA CORPORATION (US) | 2005-05-12 | — | — | WO | disclosed |