Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 11/20 | 0.64 |
| ▸ | CSF1R | P07333 | 9/20 | 0.64 |
| ▸ | KDR | P35968 | 6/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 6/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598693 | 0.89 | PDGFRB (0.81) | PDGFRBCSF1RKDRFLT3MET | |
| SCHEMBL2176626 | 0.89 | PDGFRB (0.81) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL5598876 | 0.86 | PDGFRB (0.60) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL2174541 | 0.84 | PDGFRB (0.69) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL5598622 | 0.84 | PDGFRB (0.60) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL5598979 | 0.81 | CSF1R (0.64) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL5610715 | 0.79 | SMN1; SMN2 (0.55) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL4514639 | 0.79 | PDGFRB (0.77) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL4209677 | 0.79 | PDGFRB (0.77) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL4498740 | 0.78 | PDGFRB (0.79) | PDGFRBCSF1RKDRFLT3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |