Sugi Predict

Sugi Predict / Compounds / SCHEMBL5599057

SCHEMBL5599057

SCHEMBL5599057

COc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(OC)c(O)c2)cc1O

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.89
▸ APP P05067 3/20 0.89
▸ BACE1 P56817 12/20 0.84
▸ CYP2D6 P10635 2/20 0.77
▸ CYP2C9 P11712 2/20 0.77
▸ TSHR P16473 2/20 0.77
▸ HSD17B10 Q99714 2/20 0.77
▸ NFE2L2 Q16236 2/20 0.77
▸ MEN1 O00255 2/20 0.77
▸ ALDH1A1 P00352 2/20 0.77
▸ THRB P10828 2/20 0.77
▸ KMT2A Q03164 2/20 0.77
▸ TDP1 Q9NUW8 2/20 0.77
▸ ABCB1 P08183 2/20 0.77
▸ AKR1B1 P15121 2/20 0.77
▸ MAOA P21397 2/20 0.77
▸ MAOB P27338 2/20 0.77
▸ CYP2C19 P33261 1/20 0.77
▸ KDM4E B2RXH2 1/20 0.77
▸ PTGES O14684 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2622437 1.00 MAPT (0.89) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL14259639 0.95 MAPT (0.86) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3222158 0.94 APP (1.00) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3221529 0.94 BACE1 (0.80) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL1645393 0.94 MAPT (0.80) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3211827 0.94 MAPT (0.80) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3222140 0.94 APP (1.00) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL1645395 0.94 MAPT (0.80) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3211814 0.94 MAPT (0.80) MAPTAPPBACE1CYP2D6CYP2C9
SCHEMBL3221512 0.94 BACE1 (0.80) MAPTAPPBACE1CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160039734-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC UNM (US) 2016-02-11 — — US disclosed
US-9187397-B2 Therapeutic curcumin derivatives STC.UNM (US) 2015-11-17 — — US disclosed
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES STC.UNM 2015-01-08 — — US disclosed
US-8841326-B2 Therapeutic curcumin derivatives STC.UNM (US) 2014-09-23 — — US disclosed
US-20070060644-A1 Therapeutic curcumin derivatives STC.UNM 2007-03-15 — — US disclosed
US-20060276536-A1 Cancer treatment using curcumin derivatives STC.UNM 2006-12-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160039734-A1 THERAPEUTIC CURCUMIN DERIVATIVES FABP2, GLS2, FABP1 MAPT 448/4885APP 662/4885BACE1 750/4885
US-20070060644-A1 Therapeutic curcumin derivatives FABP2, GLS2, FABP1 MAPT 448/4885APP 662/4885BACE1 750/4885
US-20150011494-A1 THERAPEUTIC CURCUMIN DERIVATIVES FABP2, GLS2, FABP1 MAPT 448/4885APP 662/4885BACE1 750/4885
US-20060276536-A1 Cancer treatment using curcumin derivatives BRCA1, VHL, TP53 MAPT 2066/4885APP 3170/4885BACE1 2553/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.