Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 6/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223344 | 0.81 | NOTUM (0.41) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL20955681 | 0.79 | KDM1A (0.34) | KDM1AACACBNR1H2USP30 | |
| SCHEMBL1222469 | 0.75 | NOTUM (0.53) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL30413026 | 0.75 | NOTUM (0.53) | KDM1AHDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL25232027 | 0.74 | NOTUM (0.52) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL1195029 | 0.74 | AKT1 (0.41) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL20955744 | 0.74 | NOTUM (0.57) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL5599315 | 0.74 | DPP4 (0.37) | KDM1AHDAC1HDAC8HDAC6 | |
| SCHEMBL5599635 | 0.73 | HDAC1 (0.38) | KDM1AHDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL17008459 | 0.73 | AKT1 (0.41) | KDM1AHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | disclosed |
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | disclosed |