Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 14/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593072 | 0.90 | PIK3CA (0.62) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5592805 | 0.86 | PIK3CA (0.60) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5593024 | 0.85 | PIK3CA (0.56) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5592979 | 0.82 | PIK3CA (0.66) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5593013 | 0.82 | MTOR (0.57) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5592988 | 0.81 | PIK3CA (0.61) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5593037 | 0.81 | PIK3CA (0.66) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5593318 | 0.80 | PIK3CA (0.53) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL5603844 | 0.79 | PIK3CA (0.52) | MTORPIK3CAPIK3CGPIK3CDHTT | |
| SCHEMBL4934392 | 0.79 | PIK3CA (0.66) | MTORPIK3CAPIK3CGPIK3CDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007066102-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | claimed |
| WO-2007066102-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |