Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162710 | 1.00 | POLB (0.47) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3952448 | 0.85 | F10 (0.48) | F10NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL20446631 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20446539 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20446584 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13890612 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20446603 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4186097 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL75954 | 0.80 | F10 (0.56) | POLBF10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13726868 | 0.79 | F10 (0.49) | POLBF10NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791597-A2 | CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF | Merck Patent GmbH (DE) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006032342-A2 | CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF | MERCK PATENT GMBH (DE) | 2006-03-30 | — | — | WO | disclosed |