SCHEMBL5605842

SCHEMBL5605842

O=C([C@H]1C[C@@H](O)CN1)N1CCN(c2ccncc2)CC1

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 5/20 0.57
CHRM1 P11229 8/20 0.46
HDAC2 Q92769 2/20 0.44
DPP8 Q6V1X1 1/20 0.44
DPP7 Q9UHL4 1/20 0.44
ITGB3 P05106 1/20 0.43
ITGA2B P08514 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
AKR1C3 P42330 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24322435 0.81 DPP4 (0.60) DPP4SMN1; SMN2AKR1C3
SCHEMBL15092049 0.76 CHRM1 (0.54) CHRM1ITGB3ITGA2B
SCHEMBL8160432 0.74 HDAC2 (0.45) DPP4HDAC2DPP8DPP7
SCHEMBL14326434 0.73 DPP4 (0.57) DPP4HDAC2DPP8DPP7
SCHEMBL18461798 0.73 DPP4 (0.57) DPP4HDAC2DPP8DPP7
SCHEMBL5345763 0.73 DPP4 (0.53) DPP4HDAC2DPP8DPP7
SCHEMBL14326148 0.73 DPP4 (0.57) DPP4HDAC2DPP8DPP7
SCHEMBL2817637 0.73 HDAC2 (0.55) DPP4HDAC2DPP8DPP7
SCHEMBL13841894 0.73 HDAC2 (0.55) DPP4HDAC2DPP8DPP7
Hydrochloric Acid SCHEMBL2709662 0.73 DPP4 (0.98) DPP4DPP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1791597-A2 CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF Merck Patent GmbH (DE) 2007-06-06 EP disclosed
EP-1720844-A2 PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES MERCK PATENT GmbH (DE) 2006-11-15 EP disclosed
WO-2006032342-A2 CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF MERCK PATENT GMBH (DE) 2006-03-30 WO disclosed
WO-2004087646-A2 PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES MERCK PATENT GMBH (DE) 2004-10-14 WO disclosed