Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607517 | 0.93 | PIK3CD (0.44) | PIK3CDCCKBRUSP2PDE10AAPP | |
| SCHEMBL5606945 | 0.90 | PIK3CD (0.52) | PIK3CDCCKBRUSP2PDE10AMAPT | |
| SCHEMBL5606800 | 0.90 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL5607940 | 0.88 | PIK3CD (0.47) | PIK3CD | |
| SCHEMBL5607070 | 0.88 | PIK3CD (0.48) | PIK3CD | |
| SCHEMBL5262172 | 0.87 | PDE7A (0.41) | CCKBRPDE10AAPPMAPTSMN1; SMN2 | |
| SCHEMBL5606766 | 0.86 | MAPT (0.46) | USP2PDE10AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5607807 | 0.85 | PIK3CG (0.44) | PIK3CD | |
| SCHEMBL5607711 | 0.83 | PIK3CD (0.46) | PIK3CDSMN1; SMN2 | |
| SCHEMBL5606274 | 0.83 | PIK3CD (0.44) | PIK3CDCCKBRUSP2PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | claimed |
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |