Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607473 | 0.92 | PIK3CD (0.41) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5606961 | 0.91 | PIK3CD (0.43) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5607747 | 0.90 | PIK3CD (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5606852 | 0.89 | PIK3CD (0.43) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5606808 | 0.89 | PIK3CD (0.51) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5607437 | 0.88 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5607382 | 0.87 | USP2 (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5607020 | 0.86 | PIK3CG (0.44) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5259223 | 0.86 | PIK3CD (0.41) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL5607757 | 0.85 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |