Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774897 | 0.90 | LCK (0.86) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL773918 | 0.83 | LCK (1.00) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5608158 | 0.80 | LCK (0.69) | LCK | |
| SCHEMBL774822 | 0.80 | LCK (0.92) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL774081 | 0.80 | LCK (0.92) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL772665 | 0.80 | LCK (0.84) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL773854 | 0.78 | LCK (0.87) | LCK | |
| SCHEMBL773377 | 0.77 | LCK (0.76) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL772952 | 0.77 | LCK (0.76) | LCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL772499 | 0.77 | LCK (0.85) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |