Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774945 | 0.91 | LCK (0.66) | LCKMAPTMEN1KMT2APOLB | |
| SCHEMBL774478 | 0.85 | LCK (0.75) | LCKMAPTMEN1KMT2AKDM4E | |
| SCHEMBL5608168 | 0.82 | LCK (0.53) | LCKMAPTMEN1KMT2APOLB | |
| SCHEMBL6658908 | 0.80 | LCK (0.68) | LCKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL774329 | 0.80 | LCK (0.68) | LCKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL773540 | 0.79 | LCK (0.65) | LCKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL774093 | 0.78 | LCK (0.78) | LCKMAPTPOLBKDM4ENPC1 | |
| SCHEMBL774521 | 0.76 | LCK (0.85) | LCKKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL773925 | 0.76 | LCK (0.74) | LCKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL774511 | 0.74 | LCK (0.71) | LCKMAPTMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |