SCHEMBL5607759

SCHEMBL5607759

C[S+]([O-])c1c(C(=O)O)nc(-c2ccc(Cl)cc2Cl)n1-c1ccc(Cl)cc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 20/20 0.54
CNR2 P34972 18/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4472337 0.85 CNR1 (0.74) CNR1CNR2
SCHEMBL3680322 0.83 CNR1 (0.71) CNR1CNR2
1-(4-Chlorophenyl)-2-(2,4-Dichlorophenyl)-5-(Methylsulfinyl)-N-(Piperidin-1-Yl)-1H-Imidazole-4-Carboxamide (Enantiomeric Mix) SCHEMBL675964 0.82 CNR1 (0.76) CNR1CNR2
SCHEMBL6105037 0.80 CNR1 (0.66) CNR1CNR2
SCHEMBL4479377 0.79 CNR1 (0.69) CNR1CNR2
SCHEMBL4486029 0.78 CNR1 (0.68) CNR1CNR2
SCHEMBL4510726 0.78 CNR1 (0.67) CNR1CNR2
SCHEMBL6102985 0.78 CNR1 (0.67) CNR1CNR2
SCHEMBL4604530 0.78 CNR1 (0.64) CNR1CNR2
SCHEMBL4065973 0.77 CNR1 (0.69) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1756066-A1 TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS WITH A HIGH CB1/CB2 RECEPTOR SUBTYPE SELECTIVITY Solvay Pharmaceuticals B.V. (NL) 2007-02-28 EP disclosed
WO-2005118553-A1 TETRASUBSTITUTED IMIDAZOLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR MODULATORS WITH A HIGH CB1/CB2 RECEPTOR SUBTYPE SELECTIVITY SOLVAY PHARMACEUTICALS B.V. (NL) 2005-12-15 WO disclosed