Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.86 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL775446 | 0.93 | LCK (1.00) | LCKCHRNA7ALDH1A1LMNAHTT | |
| SCHEMBL772665 | 0.90 | LCK (0.84) | LCKALDH1A1 | |
| SCHEMBL773159 | 0.88 | LCK (0.90) | LCKCHRNA7ALDH1A1LMNAHTT | |
| SCHEMBL774052 | 0.88 | LCK (0.86) | LCKCHRNA7 | |
| SCHEMBL773918 | 0.82 | LCK (1.00) | LCKALDH1A1 | |
| SCHEMBL5607857 | 0.82 | LCK (0.78) | LCKCHRNA7 | |
| SCHEMBL774897 | 0.80 | LCK (0.86) | LCK | |
| SCHEMBL773377 | 0.80 | LCK (0.76) | LCKALDH1A1 | |
| SCHEMBL1539966 | 0.80 | LCK (0.67) | LCKLMNA | |
| SCHEMBL772952 | 0.80 | LCK (0.76) | LCKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |