Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608003 | 0.98 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL23895993 | 0.93 | CYP2C19 (0.40) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL5019821 | 0.78 | CYP2C19 (0.48) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL15798070 | 0.78 | CYP2C19 (0.48) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| Hydrochloric Acid SCHEMBL27856474 | 0.77 | CYP2C19 (0.47) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL1825623 | 0.76 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL9162035 | 0.75 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL3667120 | 0.75 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL27608123 | 0.75 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA | |
| SCHEMBL3369935 | 0.75 | CYP2C19 (0.45) | CYP2C19ALDH1A1USP2CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-A1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | Novartis AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | disclosed |