Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.53 |
| ▸ | FLT4 | P35916 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608316 | 0.84 | KDR (0.68) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL1683381 | 0.80 | KDR (0.77) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL5598177 | 0.74 | KDR (0.66) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL26928560 | 0.69 | KDR (1.00) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL26928301 | 0.69 | KDR (1.00) | KDRCYP3A4FGFR1FLT1ERBB2 | |
| SCHEMBL1683404 | 0.68 | KDR (0.54) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL5609458 | 0.67 | KDR (0.65) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL1683390 | 0.67 | KDR (0.78) | KDRCYP3A4FGFR1FLT1KCNH2 | |
| SCHEMBL26928144 | 0.62 | KDR (1.00) | KDRCYP3A4FGFR1FLT1ERBB2 | |
| SCHEMBL5598276 | 0.61 | KDR (0.69) | KDRCYP3A4FGFR1FLT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-A4 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1539763-A1 | AZAINDOLE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004009601-A1 | AZAINDOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-29 | — | — | WO | disclosed |