Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | STK10 | O94804 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.51 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610324 | 1.00 | KDR (0.64) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL5610331 | 0.79 | KDR (0.63) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1683487 | 0.78 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1683484 | 0.78 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL5794122 | 0.75 | KDR (0.62) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL5795253 | 0.75 | KDR (0.62) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL5610419 | 0.72 | KDR (0.62) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL5610412 | 0.72 | KDR (0.62) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL14111448 | 0.70 | KDR (0.84) | KDRCYP3A4FGFR1KCNH2STK10 | |
| SCHEMBL1683436 | 0.70 | KDR (1.00) | KDRCYP3A4FGFR1KCNH2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539763-A4 | AZAINDOLE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-08-01 | — | — | EP | disclosed |
| EP-1539763-A1 | AZAINDOLE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004009601-A1 | AZAINDOLE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-29 | — | — | WO | disclosed |