Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.58 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.58 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.58 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.58 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.58 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | PRKCG | P05129 | 2/20 | 0.55 |
| ▸ | PRKCB | P05771 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.55 |
| ▸ | PRKCH | P24723 | 2/20 | 0.55 |
| ▸ | PRKCI | P41743 | 2/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 4/20 | 0.54 |
| ▸ | AKT2 | P31751 | 3/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610889 | 0.88 | AKT1 (0.62) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL4401638 | 0.84 | PRKD3 (0.72) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL10941340 | 0.81 | AKT1 (0.55) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL4482312 | 0.81 | LPAR1 (0.60) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL9576038 | 0.80 | AKT1 (0.55) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL13697282 | 0.80 | LPAR1 (0.51) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL14842644 | 0.80 | PRKD3 (0.68) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL14843034 | 0.80 | PRKD3 (0.68) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL18519898 | 0.80 | PRKD3 (0.68) | LPAR1LPAR3LPAR6LPAR4LPAR5 | |
| SCHEMBL7032675 | 0.80 | PRKD3 (0.68) | LPAR1LPAR3LPAR6LPAR4LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748772-A2 | COMBINATION THERAPIES FOR CANCER AND PROLIFERATIVE ANGIOPATHIES | UNIVERSITY OF SOUTH FLORIDA (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005110477-A2 | COMBINATION THERAPIES FOR CANCER AND PROLIFERATIVE ANGIOPATHIES | UNIVERSITY OF SOUTH FLORIDA (US) | 2005-11-24 | — | — | WO | disclosed |