Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 11/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | VHL | P40337 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980467 | 1.00 | NR1H3 (0.47) | NR1H3NR1H2PPARGPPARAMEN1 | |
| SCHEMBL3977202 | 0.93 | NR1H3 (0.53) | NR1H3NR1H2PPARGPPARARXRA | |
| SCHEMBL3977176 | 0.90 | NR1H3 (0.51) | NR1H3NR1H2PPARGPPARAMEN1 | |
| SCHEMBL3977208 | 0.89 | CACNA1B (0.46) | NR1H3NR1H2ALDH1A1SLC6A9 | |
| SCHEMBL3975906 | 0.83 | NR1H2 (0.56) | NR1H3NR1H2PPARGMEN1KMT2A | |
| SCHEMBL3984317 | 0.81 | NR1H3 (0.47) | NR1H3NR1H2PPARGPPARAMEN1 | |
| SCHEMBL10680256 | 0.76 | CYP1A2 (0.56) | NR1H3NR1H2MEN1MAPTRXRA | |
| SCHEMBL3981981 | 0.75 | PLA2G4B (0.53) | NR1H3NR1H2PPARGPPARAMEN1 | |
| SCHEMBL3981070 | 0.74 | NR1H3 (0.41) | NR1H3NR1H2MEN1KMT2ASLC6A9 | |
| SCHEMBL3976637 | 0.73 | MRGPRX4 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802566-A1 | HEXAFLUOROISOPROPANOL SUBSTITUTED ETHER DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-04 | — | — | EP | claimed |
| WO-2006037480-A1 | HEXAFLUOROISOPROPANOL SUBSTITUTED ETHER DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-13 | — | — | WO | claimed |