Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370020 | 1.00 | NR1H2 (0.36) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL2936646 | 0.86 | NR1H2 (0.38) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL14801559 | 0.81 | PDE4B (0.43) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL16096256 | 0.81 | NR1H2 (0.49) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL2929277 | 0.81 | NR1H2 (0.49) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL14805516 | 0.81 | PDE4B (0.43) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL1018269 | 0.81 | NR1H2 (0.49) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL17841916 | 0.81 | NR1H2 (0.43) | NR1H2GLSNAMPTHTTATM | |
| SCHEMBL30455847 | 0.80 | NR1H2 (0.43) | NR1H2NAMPTHTTATMMEN1 | |
| SCHEMBL17841925 | 0.79 | NR1H2 (0.41) | NR1H2GLSNAMPTHTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-A1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | Novartis AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | disclosed |