Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.73 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.73 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.73 |
| ▸ | AKT1 | P31749 | 6/20 | 0.73 |
| ▸ | MTOR | P42345 | 6/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.51 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5615215 | 0.92 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5653651 | 0.92 | PIK3CA (0.72) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614520 | 0.89 | PIK3CA (0.75) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614674 | 0.88 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614860 | 0.87 | PIK3CA (0.73) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614652 | 0.87 | PIK3CA (0.73) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614339 | 0.85 | PIK3CA (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5655178 | 0.84 | PIK3CA (1.00) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL29703086 | 0.84 | PIK3CA (1.00) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 | |
| SCHEMBL5614493 | 0.84 | PIK3CA (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511576-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1689747-A1 | 1H-IMIDAZO [4,5-C] QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | claimed |
| WO-2005054238-A1 | 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2005-06-16 | — | — | WO | claimed |