Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618618 | 1.00 | MAPT (0.46) | MAPTPOLBTDP1FLT4KDR | |
| SCHEMBL5618996 | 0.90 | BRD4 (0.49) | MAPTPOLBFLT4KDRFLT3 | |
| SCHEMBL5618999 | 0.90 | BRD4 (0.49) | MAPTPOLBFLT4KDRFLT3 | |
| SCHEMBL14515163 | 0.90 | BRD4 (0.49) | MAPTPOLBFLT4KDRFLT3 | |
| SCHEMBL5618966 | 0.84 | FLT4 (0.41) | MAPTPOLBTDP1FLT4KDR | |
| SCHEMBL5618970 | 0.84 | FLT4 (0.41) | MAPTPOLBTDP1FLT4KDR | |
| SCHEMBL14515156 | 0.84 | FLT4 (0.41) | MAPTPOLBTDP1FLT4KDR | |
| SCHEMBL7089175 | 0.77 | PDPK1 (0.45) | MAPTPOLBFLT4KDRFLT3 | |
| SCHEMBL7089182 | 0.77 | PDPK1 (0.45) | MAPTPOLBFLT4KDRFLT3 | |
| SCHEMBL3155450 | 0.77 | FLT4 (0.47) | MAPTPOLBFLT4KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7214700-B2 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214700-B2 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-7214700-B2 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20040039196-A1 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN, INC. | 2004-02-26 | — | — | US | disclosed |
| US-20030216462-A1 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | SUGEN, INC. | 2003-11-20 | — | — | US | disclosed |
| US-20020028828-A1 | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors | SUGEN, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028828-A1 | (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors | MAPKAPK2, MAPKAPK3, MAP3K2 | MAPT 3722/4885POLB 3709/4885TDP1 2581/4885 |
| US-20040039196-A1 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | MAPKAPK2, MAPKAPK3, MAP3K2 | MAPT 3722/4885POLB 3709/4885TDP1 2581/4885 |
| US-20030216462-A1 | (2-Oxindol-3-ylidenyl) acetic acid derivatives and their use as protein kinase inhibitors | MAPKAPK2, MAPKAPK3, MAP3K2 | MAPT 3722/4885POLB 3709/4885TDP1 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.