Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561623 | 0.84 | SCN9A (0.54) | SCN9A | |
| SCHEMBL281597 | 0.82 | SCN9A (1.00) | SCN9AHTTALDH1A1KDM4ELMNA | |
| SCHEMBL4596915 | 0.75 | SCN9A (0.63) | SCN9AALDH1A1 | |
| SCHEMBL5431005 | 0.74 | SCN9A (0.68) | SCN9A | |
| SCHEMBL4903741 | 0.73 | SCN9A (0.73) | SCN9AHTTALDH1A1 | |
| SCHEMBL4597686 | 0.73 | SCN9A (0.73) | SCN9A | |
| SCHEMBL281769 | 0.70 | SCN9A (0.75) | SCN9AALDH1A1HSD17B10 | |
| SCHEMBL282036 | 0.69 | SCN9A (0.74) | SCN9AALDH1A1HSD17B10 | |
| SCHEMBL4731879 | 0.69 | SCN9A (0.70) | SCN9A | |
| SCHEMBL281923 | 0.67 | SCN9A (0.57) | SCN9AALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035199-A9 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| EP-1888592-B1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2011-04-06 | — | — | EP | disclosed |
| US-20110034500-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2011-02-10 | — | — | US | disclosed |
| US-7799798-B2 | Spiroheterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2010-09-21 | — | — | US | disclosed |
| US-20060252758-A1 | Spiroheterocyclic compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252758-A1 | Spiroheterocyclic compounds and their uses as therapeutic agents | SCN3A, SCN1B, SCN2B | SCN9A 51/4885HTT 1761/4885ALDH1A1 1435/4885 |
| US-20110034500-A1 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | SCN3A, SCN1B, SCN2B | SCN9A 29/4885HTT 1983/4885ALDH1A1 1200/4885 |
| US-20120035199-A9 | SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | SCN3A, SCN1B, SCN2B | SCN9A 29/4885HTT 1983/4885ALDH1A1 1200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.