Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 6/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427944 | 0.85 | PSEN1 (0.51) | XIAPSCN9ASCN10ARIPK1 | |
| SCHEMBL13310781 | 0.82 | SCN9A (0.53) | XIAPSCN9ASCN10ARIPK1 | |
| SCHEMBL4427306 | 0.82 | SCN9A (0.53) | XIAPSCN9ASCN10ARIPK1 | |
| SCHEMBL4427298 | 0.82 | SCN9A (0.53) | XIAPSCN9ASCN10ARIPK1 | |
| SCHEMBL5619780 | 0.82 | XIAP (0.44) | XIAPSCN9ASCN10ARIPK1 | |
| SCHEMBL4434109 | 0.74 | PSEN1 (0.49) | XIAPSCN9ARIPK1MMEACE | |
| SCHEMBL5620305 | 0.74 | MEN1 (0.35) | XIAP | |
| SCHEMBL5620313 | 0.74 | MEN1 (0.35) | XIAP | |
| SCHEMBL4427314 | 0.73 | PSEN1 (0.49) | XIAPSCN9ARIPK1MMEACE | |
| Hydrochloric Acid SCHEMBL4433664 | 0.73 | XIAP (0.34) | XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673347-B1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | HOFFMAN-LA ROCHE INC. | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | BCHE, CHRM1, ADCY7 | XIAP 4834/4885SCN9A 512/4885SCN10A 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.