Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.67 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622558 | 0.94 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL5621671 | 0.87 | PARP1 (0.71) | PARP1PARP2 | |
| SCHEMBL7467348 | 0.85 | PARP1 (0.47) | PARP1HSD11B1HTR2B | |
| SCHEMBL5621966 | 0.85 | PARP1 (0.77) | PARP1PARP2 | |
| SCHEMBL7038340 | 0.84 | PARP1 (0.48) | PARP1HSD11B1HTR2B | |
| SCHEMBL5620547 | 0.83 | PARP1 (0.66) | PARP1PARP2 | |
| SCHEMBL5620204 | 0.83 | PARP1 (0.90) | PARP1PARP2 | |
| SCHEMBL5620889 | 0.81 | PARP1 (0.71) | PARP1PARP2 | |
| SCHEMBL5620535 | 0.81 | PARP1 (0.71) | PARP1PARP2 | |
| SCHEMBL5621181 | 0.80 | PARP1 (0.58) | PARP1HSD11B1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39608-E1 | Substituted benzimidazoles and their use as PARP inhibitors | ABBOTT GMBH & CO. KG (DE) | 2007-05-01 | — | — | US | disclosed |
| US-6448271-B1 | SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-10 | — | — | US | disclosed |