Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707250 | 0.96 | PTPN1 (0.38) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| SCHEMBL4706831 | 0.91 | PTPN1 (0.41) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| Trifluoroacetic Acid SCHEMBL5619985 | 0.87 | PTPN1 (0.47) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| SCHEMBL4705440 | 0.87 | PTPN1 (0.52) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| Trifluoroacetic Acid SCHEMBL4707248 | 0.86 | PTPN1 (0.42) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| SCHEMBL4706007 | 0.85 | PTPN1 (0.36) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| Trifluoroacetic Acid SCHEMBL4705990 | 0.85 | PTPN1 (0.46) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| SCHEMBL4705744 | 0.85 | PTPN1 (0.46) | PTPN1CYP3A4CYP1A2CYP2C19CLK4 | |
| SCHEMBL4708062 | 0.85 | GBA1 (0.43) | SYKALDH1A1TLR7MEN1GBA1 | |
| SCHEMBL4706999 | 0.84 | SYK (0.40) | SYKCYP2D6TLR7MEN1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226915-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-20040229890-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | BERTHEL STEVEN JOSEPH (US) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229890-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | PTPN5, PTPRO, PTPN18 | PTPN1 10/4885CYP3A4 2879/4885CYP1A2 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.