⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7397729 | 1.00 | — | — | |
| SCHEMBL19080640 | 0.81 | — | — | |
| SCHEMBL10438765 | 0.77 | NPC1 (0.38) | — | |
| SCHEMBL14888868 | 0.76 | — | — | |
| SCHEMBL9658948 | 0.76 | — | — | |
| SCHEMBL14311826 | 0.76 | — | — | |
| SCHEMBL11055340 | 0.75 | OR51E2 (0.39) | — | |
| Bicarbonate SCHEMBL10697021 | 0.74 | HTT (0.36) | — | |
| SCHEMBL6656227 | 0.74 | OR51E2 (0.42) | — | |
| Hydrochloric Acid SCHEMBL14342905 | 0.74 | NPC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673347-B1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2015-08-19 | — | — | EP | disclosed |
| CN-1894217-B | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors | HOFFMANN LA ROCHE | 2011-09-21 | — | — | CN | disclosed |
| US-7166587-B2 | Carbamic acid alkyl ester derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-01-23 | — | — | US | disclosed |
| CN-1894217-A | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | CN | disclosed |
| EP-1673347-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. Hoffman-la Roche AG (CH) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040126-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
| US-20050075327-A1 | Carbamic acid alkyl ester derivatives | HOFFMAN-LA ROCHE INC. | 2005-04-07 | — | — | US | disclosed |
| EP-0885288-A1 | BODY SOAP COMPOSITION | Johnson & Johnson Kabushiki Kaisha (JP) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997027279-A1 | BODY SOAP COMPOSITION | JOHNSON & JOHNSON KABUSHIKI KAISHA (JP) | 1997-07-31 | — | — | WO | disclosed |
| EP-0535042-B1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| US-5348978-A | Angiotensin converting enzyme inhibitors | FISONS PLC (GB) | 1994-09-20 | — | — | US | disclosed |
| EP-0350892-B1 | HEAT-CURABLE COATING COMPOSITIONS AND THEIR USE | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0535042-A1 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS. | FISONS PLC (GB) | 1993-04-07 | — | — | EP | disclosed |
| WO-1992000276-A2 | ANGIOTENSIS CONVERTING ENZYME INHIBITORS | FISONS PLC (GB) | 1992-01-09 | — | — | WO | disclosed |
| EP-0350892-A2 | Heat-curable coating compositions and their use | Herberts Gesellschaft mit beschränkter Haftung (DE) | 1990-01-17 | — | — | EP | disclosed |