Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705473 | 0.99 | PARP1 (0.56) | PARP1PARP2THRBHTR1A | |
| SCHEMBL5619904 | 0.89 | PARP1 (0.67) | PARP1PARP2THRBTERT | |
| SCHEMBL5622515 | 0.88 | PARP1 (0.61) | PARP1PARP2THRB | |
| SCHEMBL5621717 | 0.87 | PARP1 (0.60) | PARP1PARP2 | |
| SCHEMBL5621375 | 0.86 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL7041326 | 0.86 | PARP1 (0.43) | PARP1THRBTERT | |
| SCHEMBL5620956 | 0.86 | PARP1 (0.57) | PARP1PARP2HTR1A | |
| SCHEMBL5621063 | 0.86 | PARP1 (0.57) | PARP1PARP2HTR1A | |
| SCHEMBL5620500 | 0.86 | PARP1 (0.59) | PARP1PARP2HTR1A | |
| SCHEMBL5621352 | 0.85 | PARP1 (0.52) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39608-E1 | Substituted benzimidazoles and their use as PARP inhibitors | ABBOTT GMBH & CO. KG (DE) | 2007-05-01 | — | — | US | disclosed |