Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.69 |
| ▸ | AURKA | O14965 | 11/20 | 0.69 |
| ▸ | CDK9 | P50750 | 11/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.69 |
| ▸ | CDK7 | P50613 | 9/20 | 0.69 |
| ▸ | CDK1 | P06493 | 8/20 | 0.69 |
| ▸ | CDK4 | P11802 | 13/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.59 |
| ▸ | WEE1 | P30291 | 3/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621875 | 0.89 | CDK2 (0.55) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL5620027 | 0.89 | CDK2 (0.67) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL5785189 | 0.85 | CDK2 (0.52) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL4171151 | 0.85 | CDK2 (0.78) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL5620620 | 0.85 | CDK2 (0.69) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL6156585 | 0.84 | CDK2 (0.71) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL2289132 | 0.84 | CDK2 (0.51) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL5781649 | 0.83 | CDK2 (0.67) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL4165787 | 0.83 | CDK2 (0.77) | CDK2AURKACDK9AURKBCDK7 | |
| SCHEMBL4803155 | 0.83 | CDK2 (0.71) | CDK2AURKACDK9AURKBCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007500178-A | — | — | 2007-01-11 | — | — | JP | claimed |
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | CYCLACEL LIMITED (GB) | 2006-10-26 | — | — | US | claimed |
| EP-1648887-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | claimed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | CYCLACEL LIMITED (GB) | 2006-10-26 | — | — | US | disclosed |
| EP-1648887-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241297-A1 | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors | FRK, CNKSR1, TYK2 | CDK2 8/4885AURKA 611/4885CDK9 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.