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SCHEMBL5621682

SCHEMBL5621682

Cc1cc(S(=O)(=O)NCc2nn(-c3ccc(Cl)cc3Cl)c(-c3ccc(Cl)cc3)c2C#N)c(C(F)(F)F)o1.N#Cc1c(CNS(=O)(=O)Cc2ccccc2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.40

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 6/20 0.39
▸ CNR1 P21554 2/20 0.38
▸ LPAR5 Q9H1C0 2/20 0.38
▸ OPRL1 P41146 2/20 0.38
▸ KCNH2 Q12809 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL908399 0.93 OPRL1 (0.43) CNR2CNR1OPRL1KCNH2
SCHEMBL909029 0.85 CNR1 (0.47) CNR2CNR1OPRL1KCNH2
SCHEMBL908870 0.78 SLC22A12 (0.48) CNR2CNR1OPRL1KCNH2
SCHEMBL909395 0.74 CNR1 (0.49) CNR2CNR1OPRL1KCNH2
SCHEMBL908264 0.74 CNR1 (0.47) CNR2CNR1OPRL1KCNH2
SCHEMBL909140 0.74 CNR1 (0.47) CNR2CNR1OPRL1KCNH2
SCHEMBL909118 0.72 CNR1 (0.47) CNR1
SCHEMBL908989 0.71 CNR1 (0.51) CNR1OPRL1KCNH2
SCHEMBL908716 0.71 SLC22A12 (0.47) CNR1
SCHEMBL909208 0.71 CNR1 (0.44) CNR2CNR1OPRL1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7297710-B1 Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics SANOFI-AVENTIS (FR) 2007-11-20 — — US disclosed