Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 17/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 17/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 17/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 17/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622448 | 0.83 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8273809 | 0.80 | MAPK13 (0.44) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3890697 | 0.79 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3890691 | 0.79 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3877389 | 0.78 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3880327 | 0.78 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5623831 | 0.76 | MAPK13 (0.38) | MAPK13MAPK12MAPK11MAPK14DYRK1A | |
| SCHEMBL5622451 | 0.74 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3884933 | 0.73 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14DYRK1A | |
| SCHEMBL3884925 | 0.73 | MAPK14 (0.64) | MAPK13MAPK12MAPK11MAPK14DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007510739-A | — | — | 2007-04-26 | — | — | JP | claimed |
| EP-1682551-A2 | BICYCLIC PYRAZOLONE CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005047287-A2 | BICYCLIC PYRAZOLONE CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-05-26 | — | — | WO | claimed |