Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.66 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.66 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5631398 | 0.94 | MAPK14 (0.74) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5632201 | 0.84 | MAPK14 (0.79) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5632191 | 0.82 | MAPK14 (0.55) | MAPK14CYP2C9MAPK11 | |
| SCHEMBL6744546 | 0.80 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL13715287 | 0.79 | MAPK14 (0.77) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5631551 | 0.78 | MAPK14 (0.75) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5630113 | 0.78 | MAPK14 (0.89) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5633653 | 0.77 | MAPK14 (0.67) | MAPK14CYP2C9MAPK11HSPB1 | |
| SCHEMBL5631004 | 0.76 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11HSPB1 | |
| Gw782912X SCHEMBL6747431 | 0.76 | MAPK14 (1.00) | MAPK14CYP2C9MAPK11HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7208629-B2 | 5′-Carbamoyl-1,1-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-04-24 | — | — | US | disclosed |