Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | TSPO | P30536 | 2/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218869 | 0.94 | C5AR1 (0.37) | C5AR1PTGDR2TSPOGNRHRCNR2 | |
| SCHEMBL648586 | 0.90 | C5AR1 (0.39) | C5AR1TSPOMAPTRXFP1PPARG | |
| SCHEMBL5633847 | 0.90 | C5AR1 (0.53) | C5AR1GNRHRMAPTPPARGPPARA | |
| SCHEMBL5225249 | 0.89 | C5AR1 (0.38) | C5AR1PTGDR2GNRHRMAPTCNR2 | |
| SCHEMBL648694 | 0.88 | C5AR1 (0.39) | C5AR1TSPOGNRHRMAPTRXFP1 | |
| SCHEMBL648900 | 0.86 | C5AR1 (0.42) | C5AR1MAPTNR1H3PPARGPPARA | |
| SCHEMBL651426 | 0.85 | C5AR1 (0.38) | C5AR1PPARGHDAC1PARP1 | |
| SCHEMBL648253 | 0.85 | TSHR (0.41) | C5AR1TSPOGNRHRMAPTRXFP1 | |
| SCHEMBL650278 | 0.85 | C5AR1 (0.40) | C5AR1TSPOCNR2PPARGHDAC1 | |
| SCHEMBL648873 | 0.84 | MC4R (0.37) | C5AR1NR1H3PPARGHDAC1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |