Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | CDK8 | P49336 | 3/20 | 0.59 |
| ▸ | RAF1 | P04049 | 10/20 | 0.58 |
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MUSK | O15146 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442586 | 0.92 | RET (0.58) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL6030307 | 0.91 | RET (0.63) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL5634874 | 0.91 | RAF1 (0.61) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL5636194 | 0.90 | RAF1 (0.64) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL13648129 | 0.87 | RET (0.64) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL5635415 | 0.85 | RET (0.86) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL5636169 | 0.84 | RAF1 (0.65) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL4445772 | 0.84 | CDK8 (0.56) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL101750 | 0.83 | RET (0.57) | RETCDK8RAF1BRAFKDR | |
| SCHEMBL4442142 | 0.82 | RAF1 (0.60) | RETCDK8RAF1BRAFCA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| EP-1641759-B1 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-03-12 | — | — | EP | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| US-20070213374-A1 | Malonamide Derivatives | MERCK PATENT GMBH (DE) | 2007-09-13 | — | — | US | disclosed |
| EP-1641759-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005005389-A2 | MALONAMIDE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213374-A1 | Malonamide Derivatives | RAF1, BRAF, ARAF | RET 350/4885CDK8 503/4885RAF1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.