⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233735 | 0.86 | — | — | |
| SCHEMBL4987430 | 0.78 | — | — | |
| SCHEMBL302733 | 0.78 | — | — | |
| SCHEMBL11025010 | 0.65 | — | — | |
| SCHEMBL31096364 | 0.64 | — | — | |
| SCHEMBL28838001 | 0.61 | — | — | |
| SCHEMBL10613859 | 0.61 | — | — | |
| SCHEMBL899228 | 0.61 | — | — | |
| SCHEMBL9317793 | 0.61 | — | — | |
| SCHEMBL162584 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660493-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005023804-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | WO | claimed |
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | US | claimed |
| US-20030008829-A1 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | COSTANZO MICHAEL J (US) | 2003-01-09 | — | — | US | claimed |
| EP-0571579-B1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | CHEMOPETROL A S (CS) | 1998-04-01 | — | — | EP | claimed |
| US-5455318-A | Metathetical polymerization in presence of catalyst based on tungsten compound reacted with sterically hindered amine and solution of cocatalyst | CHEMOPETROL, S.P. LITVINOV, VYZKUMNY USTAV MAKROMOLEKULARNI CHEMIE (CS) | 1995-10-03 | — | — | US | claimed |
| EP-0571579-A1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | Chemopetrol, a.s (CS) | 1993-12-01 | — | — | EP | claimed |
| WO-1993012158-A1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | CHEMOPETROL, S.P. LITVÍNOV VY^´ZKUMNY^´ ÚSTAV MAKROMOLEKULÁRNÍ CHEMIE (CS) | 1993-06-24 | — | — | WO | claimed |
| JP-4230341-A | — | — | None | — | — | JP | disclosed |
| US-7205384-B2 | Process for preparing peptidyl heterocyclic ketone derivatives | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7132418-B2 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| EP-1660493-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005023804-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | WO | disclosed |
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | US | disclosed |
| WO-2000044733-A1 | PEPTIDYL HETEROCYCLIC KETONES USEFUL AS TRYPTASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-08-03 | — | — | WO | disclosed |
| EP-0571579-B1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | CHEMOPETROL A S (CS) | 1998-04-01 | — | — | EP | disclosed |
| US-5455318-A | Metathetical polymerization in presence of catalyst based on tungsten compound reacted with sterically hindered amine and solution of cocatalyst | CHEMOPETROL, S.P. LITVINOV, VYZKUMNY USTAV MAKROMOLEKULARNI CHEMIE (CS) | 1995-10-03 | — | — | US | disclosed |
| EP-0571579-A1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | Chemopetrol, a.s (CS) | 1993-12-01 | — | — | EP | disclosed |
| WO-1993012158-A1 | METHOD OF PRODUCTION OF POLYMERS AND COPOLYMERS OF CYCLOALKENE OF NORBORNENE TYPE | CHEMOPETROL, S.P. LITVÍNOV VY^´ZKUMNY^´ ÚSTAV MAKROMOLEKULÁRNÍ CHEMIE (CS) | 1993-06-24 | — | — | WO | disclosed |
| JP-H04230341-A | POLYMERIZABLE OXIDATION INHIBITOR, AND POLYOLEFIN AND POLYMERIZATION METHOD FOR PRODUCING POLYOLEFIN | STAMICARBON BV | 1992-08-19 | — | — | JP | disclosed |