Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 16/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191074 | 0.93 | CHRM1 (0.61) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL29822414 | 0.87 | CHRM1 (0.49) | CHRM1CHRM4CHRM5ALDH1A1TSHR | |
| SCHEMBL12131804 | 0.86 | CHRM1 (0.53) | CHRM1CHRM2CHRM4CHRM5ALDH1A1 | |
| SCHEMBL17354962 | 0.85 | CHRM1 (0.51) | CHRM1CHRM4CHRM5ALDH1A1TSHR | |
| SCHEMBL10063523 | 0.85 | CHRM1 (0.51) | CHRM1CHRM4CHRM5ALDH1A1TSHR | |
| SCHEMBL5636057 | 0.81 | CHRM1 (0.56) | CHRM1CHRM2CHRM3CHRM4ALDH1A1 | |
| SCHEMBL12128830 | 0.81 | CHRM1 (0.47) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL5636192 | 0.81 | CHRM1 (0.44) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL14145633 | 0.81 | CHRM1 (0.56) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL3744007 | 0.80 | CHRM1 (0.46) | CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054912-A1 | Modulators of acetylcholine receptors | ASTLES PETER C | 2007-03-08 | — | — | US | disclosed |
| US-7148236-B2 | Modulators of acetylcholine receptors | MERCK & CO., INC. (US) | 2006-12-12 | — | — | US | disclosed |
| US-20050182088-A1 | Modulators of acetylcholine receptors | MERCK SHARP & DOHME CORP. | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182088-A1 | Modulators of acetylcholine receptors | CHRM3, CHRNG, CHRM5 | CHRM1 22/4885CHRM2 17/4885CHRM3 1/4885 |
| US-20070054912-A1 | Modulators of acetylcholine receptors | CHRM3, CHRNG, CHRM5 | CHRM1 17/4885CHRM2 6/4885CHRM3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.