Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14381384 | 1.00 | GPR183 (0.42) | GPR183L3MBTL1MAPK1KMT2AAPP | |
| SCHEMBL4029838 | 0.92 | CHRNA7 (0.46) | GPR183L3MBTL1MAPK1KMT2AAPP | |
| SCHEMBL13887191 | 0.92 | CHRNA7 (0.46) | GPR183L3MBTL1MAPK1KMT2AAPP | |
| SCHEMBL4027623 | 0.77 | HPGD (0.60) | MAPK1CHRNA7HTR3AMAPTNPC1 | |
| SCHEMBL372772 | 0.73 | CHRNA7 (0.54) | KMT2ACHRNA7HTR3AMAPTNPC1 | |
| SCHEMBL6153257 | 0.72 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL5987674 | 0.72 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL6153018 | 0.72 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL5987676 | 0.72 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL6152740 | 0.72 | CHRNA7 (0.51) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | claimed |
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | disclosed |
| EP-1699802-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061511-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244097-A1 | Nicotinic AcetylcholineReceptor Ligands | CHRNG, CHRNE, CHRNA1 | GPR183 167/4885L3MBTL1 3672/4885MAPK1 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.