Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520708 | 0.90 | POLB (0.47) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5639463 | 0.87 | HPGD (0.44) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5639539 | 0.87 | HPGD (0.44) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5637557 | 0.86 | HPGD (0.47) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5639104 | 0.86 | HPGD (0.47) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5635813 | 0.82 | HPGD (0.47) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5637599 | 0.80 | HPGD (0.43) | HPGDCYP3A4CYP2C19POLBLMNA | |
| SCHEMBL4540695 | 0.79 | HPGD (0.50) | HPGDPOLBLMNAHTTMEN1 | |
| Trifluoroacetic Acid SCHEMBL5639310 | 0.78 | ALOX5AP (0.41) | HPGDCYP3A4CYP2C19POLBLMNA | |
| Trifluoroacetic Acid SCHEMBL5639024 | 0.78 | ALOX5AP (0.41) | HPGDCYP3A4CYP2C19POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7179802-B2 | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2007-02-20 | — | — | US | disclosed |