Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GCGR | P47871 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639954 | 0.91 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5637592 | 0.91 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5638390 | 0.90 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5637540 | 0.87 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5641650 | 0.87 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5637234 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5638394 | 0.80 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5640777 | 0.79 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL5641653 | 0.79 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5641063 | 0.78 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253191-B2 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2007-08-07 | — | — | US | disclosed |
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-20040116416-A1 | 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry | MERCKLE GMBH (DE) | 2004-06-17 | — | — | US | disclosed |